Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revision Previous revision
case_studies [2010/04/12 19:48]
elizkurb
case_studies [2010/05/02 02:44] (current)
ejmann
Line 3: Line 3:
 //D. Smilek, B.A. Moffatt, J. Pasternak, B.N. White, M.J. Dixon, and P.M. Merikle// //D. Smilek, B.A. Moffatt, J. Pasternak, B.N. White, M.J. Dixon, and P.M. Merikle//
  
-**Case Study: Monozygotic Twins**+===== Case Study: Monozygotic Twins =====
  
 Identical 11-year old twin sisters, EB and JB were used in this case study. EB reports experiencing synesthetic color for the digits 1 through 9, while her sister JB reports no synesthetic experience. Identical 11-year old twin sisters, EB and JB were used in this case study. EB reports experiencing synesthetic color for the digits 1 through 9, while her sister JB reports no synesthetic experience.
Line 9: Line 9:
 The case study had two components. The first was a genotypic analysis conducted to determine the EB and JB are monozygotic twins. The results of the genotypic analysis strongly suggested that EB and JB are monozygotic twins. The second part of the study was a phenotypic analysis conducted to find evidence proving EB and JB's differing perceptual experience and establish that EB has synesthesia. The case study had two components. The first was a genotypic analysis conducted to determine the EB and JB are monozygotic twins. The results of the genotypic analysis strongly suggested that EB and JB are monozygotic twins. The second part of the study was a phenotypic analysis conducted to find evidence proving EB and JB's differing perceptual experience and establish that EB has synesthesia.
  
-**Phenotypic Analysis**+===== Phenotypic Analysis ​=====
  
 The phenotypic analysis involved a performance on a variety of Stroop tasks. EB and JB viewed color digits on computer monitors to establish synesthetic or non-synesthetic experiences. The trials featured both congruent and incongruent colored digits, and reaction time in identifying the color was measured. EB had much slower reaction times in both congruent and incongruent trials than her sister. This phenotypical analysis established that the monozygotic twins are discordant for synesthesia. The phenotypic analysis involved a performance on a variety of Stroop tasks. EB and JB viewed color digits on computer monitors to establish synesthetic or non-synesthetic experiences. The trials featured both congruent and incongruent colored digits, and reaction time in identifying the color was measured. EB had much slower reaction times in both congruent and incongruent trials than her sister. This phenotypical analysis established that the monozygotic twins are discordant for synesthesia.
  
-**Implications and Conclusions**+===== Implications and Conclusions ​=====
  
 This case study may implicate that synesthesia is an X-linked dominant trait, which provides a possible explanation for the discordance in twins. If this is true, the X-linked gene for synesthesia is inactivated in EB and not in JB. EB has a greater proportion of cells with an active affected chromosome. Further research and molecular genetic analyses of families with two or more synesthetes will hopefully determine whether there is a single gene for synesthesia and where it is located. This case study may implicate that synesthesia is an X-linked dominant trait, which provides a possible explanation for the discordance in twins. If this is true, the X-linked gene for synesthesia is inactivated in EB and not in JB. EB has a greater proportion of cells with an active affected chromosome. Further research and molecular genetic analyses of families with two or more synesthetes will hopefully determine whether there is a single gene for synesthesia and where it is located.
  
-RESOURCES+===== Related Article ===== 
   * [[http://​home.comcast.net/​~sean.day/​Smilek02.pdf|A Case Study of Discordant Monozygotic Twins]]   * [[http://​home.comcast.net/​~sean.day/​Smilek02.pdf|A Case Study of Discordant Monozygotic Twins]]
- 
- 
- 
  
 \\ \\ //​**[[synesthesia|Back to Synesthesia]]**//​ \\ \\ //​**[[synesthesia|Back to Synesthesia]]**//​